Precision, long-chain DNA.
By the year 2030, production utilizing biotechnology is expected to comprise 2.7% of global gross domestic product, an amount valued at approximately 1.7 trillion USD. This trend is not limited to the the medical and food industries, however―the use of biotechnology is anticipated to become commonplace in manufacturing and energy production as well. As mankind faces a plethora of environmental problems and critical issues of a global scale, biotechnology is poised to make enormous contributions towards humanity’s shared future. Thanks to recent advances in synthetic biology, the age is fast approaching where mankind can―through the synthesis of DNA―engineer an unlimited number of biological mechanisms.
At the core of synthetic biology is the ability to “read” and “write” DNA, which encodes the information by which biological processes take place. By utilizing Synplogen’s proprietary gene synthesis process, we hope to contribute to the richer future promised by synthetic biology and biotechnology.
A new approach
Some DNA is simply too long and complicated to be synthesized effectively using current methods, and attempting to do so typically results in the loss of important information or functionality. Synplogen delivers DNA exactly as the customer has ordered, at reasonable costs even for DNA up to 100 kbp in length or more.
The microbial production process involved in manufacturing products such as medicine, cosmetics, biomaterials, or commodity chemicals sometimes requires synthesizing genetic circuits consisting of dozens of genes. Cost-effective and combinatorial optimization of these gene clusters enables high-throughput screening of novel, more productive strains.
Medical treatment & drug development
Effective gene therapy for humans is quickly moving from the realm of science fiction to the real world. DNA applications for gene therapy often require long chains of tens of thousands of base pairs, such as optimized viral vectors with higher transduction efficiencies and lower immunogenicity. Animal disease model research is another exciting field for DNA assembly technologies.
Synplogen develops competitive DNA synthesis technologies. Two of our technologies highlighted below allow for high-throughput DNA synthesis at remarkable lengths and levels of efficiency. Synplogen’s initial technologies are the result of more than ten years of intense research and development that began at Kōbe University and which combines cutting-edge genetic engineering approaches with information science and robotics.
Long-chain DNA synthesis
Synthesis of long-chain DNA (up to 100 kbp)
Combinatorial DNA library synthesis
Synthesis of DNA libraries using combinatorial design
Support for developing production-use microbes
Assistance with the design and synthesis of gene clusters for the development of production-use microorganisms
Precision, long-chain DNA.
Remarkable efficiency. No compromises.